|
Symbol Name ID |
Braf
Braf transforming gene MGI:88190 |
| Darker colors indicate more annotations |
| Human Phenotypes | Abnormal cardiovascular system morphology |
Atrial septal defect |
Tetralogy of Fallot |
Abnormal heart valve morphology |
Abnormal aortic valve morphology |
Abnormal mitral valve morphology |
Hypertrophic cardiomyopathy |
Pulmonic stenosis |
Lymphadenopathy |
Splenomegaly |
Hepatosplenomegaly |
Cavernous hemangioma |
| Disease(s) Associated with BRAF | ||||||||||||
| cardiofaciocutaneous syndrome | ||||||||||||
| cardiofaciocutaneous syndrome 1 | ||||||||||||
| Noonan syndrome 7 | ||||||||||||
| Noonan syndrome with multiple lentigines 3 | ||||||||||||
| pancreatic cancer |
| Mouse Phenotypes | abnormal blood vessel morphology |
abnormal aorta morphology |
abnormal coronary artery morphology |
abnormal vascular endothelial cell morphology |
increased vascular endothelial cell number |
abnormal placental labyrinth vasculature morphology |
abnormal cardinal vein morphology |
abnormal vitelline vasculature morphology |
abnormal myocardial fiber morphology |
increased myocardial fiber size |
abnormal myocardial trabeculae morphology |
thin myocardium compact layer |
abnormal heart development |
abnormal atrioventricular cushion morphology |
abnormal heart morphology |
thick mitral valve cusps |
mitral valve hypertrophy |
tricuspid valve hypertrophy |
thick tricuspid valve |
atrial septal defect |
ostium secundum atrial septal defect |
patent cardiac foramen ovale |
thick interventricular septum |
ventricular septal defect |
increased heart weight |
enlarged heart |
cardiac hypertrophy |
heart hyperplasia |
abnormal pulmonary valve cusp morphology |
thick pulmonary valve cusps |
enlarged pulmonary valve |
pulmonary valve hypertrophy |
pulmonary valve stenosis |
thick pulmonary valve |
thick ventricular wall |
hemopericardium |
abnormal epicardium morphology |
pulmonary alveolar hemorrhage |
hematoma |
hemorrhage |
intraventricular hemorrhage |
poor circulation |
increased cardiac muscle contractility |
decreased heart rate |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||
| Braftm1.1Sva/Braftm1.1Sva | |||||||||||||||||||||||||||||||||||||||||||||
| Braftm1Zim/Braftm1Zim | |||||||||||||||||||||||||||||||||||||||||||||
| Braftm1Bbd/Braf+ | |||||||||||||||||||||||||||||||||||||||||||||
| Braftm1Tumg/Braf+ Tg(CAG-cre)2Osb/0 (conditional) |
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| Braftm2Cpri/Braf+ Tg(CMV-cre)1Cgn/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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